Endocrine Abstracts

Introduction: The extracellular calcium-sensing receptor (CaSR) is a G-protein coupled receptor (GPCR) that is expressed in the parathyroids and kidneys, where it allows regulation of parathyroid hormone (PTH) secretion and extracellular calcium concentrations. Inactivating heterozyogous CaSR mutations result in familial benign hypocalciuric hypercalcaemia. However, the role of CaSR polymorphisms in controlling serum calcium, PTH and bone mineral density (BMD) remains controve...